SARS-coronavirus (SARS-CoV) and the safety of a solvent/detergent (S/D) treated immunoglobulin preparation
Identifieur interne : 004652 ( Main/Exploration ); précédent : 004651; suivant : 004653SARS-coronavirus (SARS-CoV) and the safety of a solvent/detergent (S/D) treated immunoglobulin preparation
Auteurs : H. F. Rabenau [Allemagne] ; L. Biesert [Allemagne] ; T. Schmidt [Allemagne] ; G. Bauer [Allemagne] ; J. Cinatl [Allemagne] ; H. W. Doerr [Allemagne]Source :
- Biologicals [ 1045-1056 ] ; 2005.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Détergents, Solvants.
- Humains, Immunoglobulines, Inactivation virale, Virus du SRAS.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Detergents, Solvents.
- drug effects : SARS Virus.
- Humans, Immunoglobulins, Virus Inactivation.
Abstract
SARS-coronavirus (SARS-CoV) is a newly emerged, highly pathogenic agent that caused over 8000 human infections with nearly 800 deaths between November 2002 and September 2003. While direct person-to-person transmission via respiratory droplets accounted for most cases, other modes have not been ruled out. SARS-CoV viraemia does not seem to reach high titres, however, it has to be excluded that virus transmission may occur via blood transfusion or application of therapeutic plasma products, e.g. fresh-frozen plasma or single components derived thereof. Manufacturing processes of all plasma derivatives are required to comprise dedicated virus inactivation/removal steps. Treatment with a mixture of solvent and detergent (SD) has successfully been applied to inactivate the most members of the transfusion-relevant viruses without affecting therapeutic properties of the products. The SD treatment irreversibly disrupts the lipid envelope of viruses such as HIV, HBV, HCV, HGV and CMV. In this study we evaluated the manufacturing process of an immunoglobulin preparation (OCTAGAM, manufactured by Octapharma Pharmazeutika Produktionsges.m.b.H., Vienna, Austria) for its capacity to inactivate the SARS-CoV. Our results demonstrate that SARS-CoV was completely inactivated below the limit of detection. This was found to occur within 1 min of SD treatment.
Url:
DOI: 10.1016/j.biologicals.2005.01.003
PubMed: 15939287
PubMed Central: 7128630
Affiliations:
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F." last="Rabenau">H. F. Rabenau</name><affiliation wicri:level="3"><nlm:aff id="affa">Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Biesert, L" sort="Biesert, L" uniqKey="Biesert L" first="L." last="Biesert">L. Biesert</name><affiliation wicri:level="3"><nlm:aff id="affb">Octapharma Pharmazeutika Produktionsges.m.b.H., Virus & Prion Validation Department, Paul Ehrlich-St 42-44, D – 60596 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Octapharma Pharmazeutika Produktionsges.m.b.H., Virus & Prion Validation Department, Paul Ehrlich-St 42-44, D – 60596 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Schmidt, T" sort="Schmidt, T" uniqKey="Schmidt T" first="T." last="Schmidt">T. Schmidt</name><affiliation wicri:level="3"><nlm:aff id="affb">Octapharma Pharmazeutika Produktionsges.m.b.H., Virus & Prion Validation Department, Paul Ehrlich-St 42-44, D – 60596 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Octapharma Pharmazeutika Produktionsges.m.b.H., Virus & Prion Validation Department, Paul Ehrlich-St 42-44, D – 60596 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Bauer, G" sort="Bauer, G" uniqKey="Bauer G" first="G." last="Bauer">G. Bauer</name><affiliation wicri:level="3"><nlm:aff id="affa">Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Cinatl, J" sort="Cinatl, J" uniqKey="Cinatl J" first="J." last="Cinatl">J. Cinatl</name><affiliation wicri:level="3"><nlm:aff id="affa">Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author><author><name sortKey="Doerr, H W" sort="Doerr, H W" uniqKey="Doerr H" first="H. W." last="Doerr">H. W. Doerr</name><affiliation wicri:level="3"><nlm:aff id="affa">Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Virology, Frankfurt am Main University Hospital Medical School, Paul Ehrlich-Str. 40, D – 60596 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName></affiliation></author></analytic><series><title level="j">Biologicals</title><idno type="ISSN">1045-1056</idno><idno type="eISSN">1095-8320</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Detergents (pharmacology)</term><term>Humans</term><term>Immunoglobulins</term><term>SARS Virus (drug effects)</term><term>Solvents (pharmacology)</term><term>Virus Inactivation</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Détergents (pharmacologie)</term><term>Humains</term><term>Immunoglobulines</term><term>Inactivation virale</term><term>Solvants (pharmacologie)</term><term>Virus du SRAS ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Detergents</term><term>Solvents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Détergents</term><term>Solvants</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Immunoglobulins</term><term>Virus Inactivation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Immunoglobulines</term><term>Inactivation virale</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>SARS-coronavirus (SARS-CoV) is a newly emerged, highly pathogenic agent that caused over 8000 human infections with nearly 800 deaths between November 2002 and September 2003. While direct person-to-person transmission via respiratory droplets accounted for most cases, other modes have not been ruled out. SARS-CoV viraemia does not seem to reach high titres, however, it has to be excluded that virus transmission may occur via blood transfusion or application of therapeutic plasma products, e.g. fresh-frozen plasma or single components derived thereof. Manufacturing processes of all plasma derivatives are required to comprise dedicated virus inactivation/removal steps. Treatment with a mixture of solvent and detergent (SD) has successfully been applied to inactivate the most members of the transfusion-relevant viruses without affecting therapeutic properties of the products. The SD treatment irreversibly disrupts the lipid envelope of viruses such as HIV, HBV, HCV, HGV and CMV. In this study we evaluated the manufacturing process of an immunoglobulin preparation (OCTAGAM, manufactured by Octapharma Pharmazeutika Produktionsges.m.b.H., Vienna, Austria) for its capacity to inactivate the SARS-CoV. Our results demonstrate that SARS-CoV was completely inactivated below the limit of detection. This was found to occur within 1 min of SD treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Biesert, L" uniqKey="Biesert L">L. Biesert</name></author><author><name sortKey="G Rtner, T" uniqKey="G Rtner T">T. Gärtner</name></author><author><name sortKey="Lemon, S" uniqKey="Lemon S">S. Lemon</name></author><author><name sortKey="Horowitz, B" uniqKey="Horowitz B">B. Horowitz</name></author><author><name sortKey="Suhartono, S" uniqKey="Suhartono S">S. Suhartono</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biesert, L" uniqKey="Biesert L">L. Biesert</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Centers For Disease Control And Prevention Cdc" uniqKey="Centers For Disease Control And Prevention Cdc">Centers for Disease Control and Prevention (CDC)</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Günther</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S. van der Werf</name></author><author><name sortKey="Brodt, H R" uniqKey="Brodt H">H.R. Brodt</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S. Günther</name></author><author><name sortKey="Schmitz, H" uniqKey="Schmitz H">H. Schmitz</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horowitz, B" uniqKey="Horowitz B">B. Horowitz</name></author><author><name sortKey="Bonomo, R" uniqKey="Bonomo R">R. Bonomo</name></author><author><name sortKey="Prince, A M" uniqKey="Prince A">A.M. Prince</name></author><author><name sortKey="Sing, N C" uniqKey="Sing N">N.C. Sing</name></author><author><name sortKey="Brotman, B" uniqKey="Brotman B">B. Brotman</name></author><author><name sortKey="Shulman, R W" uniqKey="Shulman R">R.W. Shulman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horowitz, B" uniqKey="Horowitz B">B. Horowitz</name></author><author><name sortKey="Lazo, A" uniqKey="Lazo A">A. Lazo</name></author><author><name sortKey="Grossberg, H" uniqKey="Grossberg H">H. Grossberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horowitz, B" uniqKey="Horowitz B">B. Horowitz</name></author><author><name sortKey="Wiebe, M E" uniqKey="Wiebe M">M.E. Wiebe</name></author><author><name sortKey="Lippin, A" uniqKey="Lippin A">A. Lippin</name></author><author><name sortKey="Stryker, M H" uniqKey="Stryker M">M.H. Stryker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="K Rber, G" uniqKey="K Rber G">G. Kärber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreil, T" uniqKey="Kreil T">T. Kreil</name></author><author><name sortKey="Berting, A" uniqKey="Berting A">A. Berting</name></author><author><name sortKey="Kistner, O" uniqKey="Kistner O">O. Kistner</name></author><author><name sortKey="Kindermann, J" uniqKey="Kindermann J">J. Kindermann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, W" uniqKey="Liang W">W. Liang</name></author><author><name sortKey="Zhu, Z" uniqKey="Zhu Z">Z. Zhu</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J. Guo</name></author><author><name sortKey="Liu, Z" uniqKey="Liu Z">Z. Liu</name></author><author><name sortKey="He, X" uniqKey="He X">X. He</name></author><author><name sortKey="Zhou, W" uniqKey="Zhou W">W. Zhou</name></author><author><name sortKey="For The Beijing Joint Sars Expert Group" uniqKey="For The Beijing Joint Sars Expert Group">for the Beijing Joint SARS Expert Group (2003)</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, M A" uniqKey="Marra M">M.A. Marra</name></author><author><name sortKey="Jones, S J" uniqKey="Jones S">S.J. Jones</name></author><author><name sortKey="Astell, C R" uniqKey="Astell C">C.R. Astell</name></author><author><name sortKey="Holt, R A" uniqKey="Holt R">R.A. Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A. Brooks-Wilson</name></author><author><name sortKey="Butterfield, Y S" uniqKey="Butterfield Y">Y.S. Butterfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, J S" uniqKey="Peiris J">J.S. Peiris</name></author><author><name sortKey="Chu, C M" uniqKey="Chu C">C.M. Chu</name></author><author><name sortKey="Cheng, V C" uniqKey="Cheng V">V.C. Cheng</name></author><author><name sortKey="Chan, K S" uniqKey="Chan K">K.S. Chan</name></author><author><name sortKey="Hung, I F" uniqKey="Hung I">I.F. Hung</name></author><author><name sortKey="Poon, L L" uniqKey="Poon L">L.L. Poon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piet, M P J" uniqKey="Piet M">M.P.J. Piet</name></author><author><name sortKey="Chin, S" uniqKey="Chin S">S. Chin</name></author><author><name sortKey="Prince, A M" uniqKey="Prince A">A.M. Prince</name></author><author><name sortKey="Brotman, B" uniqKey="Brotman B">B. Brotman</name></author><author><name sortKey="Cundell, A M" uniqKey="Cundell A">A.M. Cundell</name></author><author><name sortKey="Horowitz, B" uniqKey="Horowitz B">B. Horowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rabenau, H F" uniqKey="Rabenau H">H.F. Rabenau</name></author><author><name sortKey="Cinatl, J" uniqKey="Cinatl J">J. Cinatl</name></author><author><name sortKey="Morgenstern, B" uniqKey="Morgenstern B">B. Morgenstern</name></author><author><name sortKey="Bauer, G" uniqKey="Bauer G">G. Bauer</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author><author><name sortKey="Doerr, H W" uniqKey="Doerr H">H.W. Doerr</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Rota, P A" uniqKey="Rota P">P.A. Rota</name></author><author><name sortKey="Oberste, M S" uniqKey="Oberste M">M.S. Oberste</name></author><author><name sortKey="Monroe, S S" uniqKey="Monroe S">S.S. Monroe</name></author><author><name sortKey="Nix, W A" uniqKey="Nix W">W.A. Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R. Campagnoli</name></author><author><name sortKey="Icenogle, J P" uniqKey="Icenogle J">J.P. Icenogle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, M" uniqKey="Schmidt M">M. Schmidt</name></author><author><name sortKey="Brixner, V" uniqKey="Brixner V">V. Brixner</name></author><author><name sortKey="Ruster, B" uniqKey="Ruster B">B. Ruster</name></author><author><name sortKey="Hourfar, M K" uniqKey="Hourfar M">M.K. Hourfar</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C. Drosten</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W. Preiser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seto, W H" uniqKey="Seto W">W.H. Seto</name></author><author><name sortKey="Tsang, D" uniqKey="Tsang D">D. Tsang</name></author><author><name sortKey="Yung, R W" uniqKey="Yung R">R.W. Yung</name></author><author><name sortKey="Ching, T Y" uniqKey="Ching T">T.Y. Ching</name></author><author><name sortKey="Ng, T K" uniqKey="Ng T">T.K. Ng</name></author><author><name sortKey="Ho, M" uniqKey="Ho M">M. Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spearman, C" uniqKey="Spearman C">C. Spearman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J. Wu</name></author><author><name sortKey="Xu, F" uniqKey="Xu F">F. Xu</name></author><author><name sortKey="Zhou, W" uniqKey="Zhou W">W. Zhou</name></author><author><name sortKey="Feikin, D R" uniqKey="Feikin D">D.R. Feikin</name></author><author><name sortKey="Lin, C Y" uniqKey="Lin C">C.Y. Lin</name></author><author><name sortKey="He, X" uniqKey="He X">X. He</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Rabenau, H F" sort="Rabenau, H F" uniqKey="Rabenau H" first="H. F." last="Rabenau">H. F. Rabenau</name></region><name sortKey="Bauer, G" sort="Bauer, G" uniqKey="Bauer G" first="G." last="Bauer">G. Bauer</name><name sortKey="Biesert, L" sort="Biesert, L" uniqKey="Biesert L" first="L." last="Biesert">L. Biesert</name><name sortKey="Cinatl, J" sort="Cinatl, J" uniqKey="Cinatl J" first="J." last="Cinatl">J. Cinatl</name><name sortKey="Doerr, H W" sort="Doerr, H W" uniqKey="Doerr H" first="H. W." last="Doerr">H. W. Doerr</name><name sortKey="Schmidt, T" sort="Schmidt, T" uniqKey="Schmidt T" first="T." last="Schmidt">T. 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